杨瑞阁，女，南华大学特聘教授，博士生导师，南华大学“青年优秀人才”。2005-2012年本硕就读于西北农林科技大学，2012-2015年在康龙化成（西安）新药技术有限公司从事药物研发工作，2018年博士毕业于西北农林科技大学化学生物学专业。主要从事中药活性物质的发现、结构优化、生物活性评价及其作用机制研究；药用植物资源的可持续利用与保护。主持中国自然科学基金青年科学基金、中国博士后面上、河南省重点研发与推广专项（科技攻关）等项目。以第一/通讯作者在J. Med. Chem.、Eur. J. Med. Chem.、Chinese Chem.Let.、J. Agri. Food Chem.等SCI期刊发表论文20多篇，其中中科院1区Top 16篇，ESI高被引论文1篇。
1.XuT.1,Yan X. T.1, KangA. Y., YangL. H., LiX. H., TianY.,YangR.G.*, QinS. S.*,GuoY.*Development ofmembrane-targetingfluorescent 2-phenyl-1H-phenanthro[9,10-d]imidazole-antimicrobialpeptidemimicconjugates againstmethicillin-resistantStaphylococcus aureus.Journal of Medicinal Chemistry,2024,https://doi.org/10.1021/acs.jmedchem.4c00436.
2.Yao, H., Cui, L.P., Liu, H., Li, X.Y., Shen, L.,Yang, R.G.*, Qin, S. S.*.,Guo, Y.*Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms.Chinese Chemical Letters,2024, 108511.
3.Yang R.G.1, Cheng W. Q.1, Huang M. J., Xu T., Zhang M. M., Liu J. F., Qin S. S., Guo Y.* Novel membrane-targeting isoxanthohumol-amine conjugates for combating methicillin- resistantStaphylococcus aureus(MRSA) infections.European Journal of Medicinal Chemistry,2024, 268, 116274.
4.Cheng, W.Q., Xu, T., Cui, L.P., Xue, Z.H., Liu, J.F.,Yang, R.G.*, Qin, S. S.*, Guo, Y.* Discovery of Amphiphilic Xanthohumol Derivatives as Membrane-Targeting Antimicrobials against Methicillin-ResistantStaphylococcus aureus.Journal of Medicinal Chemistry,2023, 66(1), 962-975.
5.Yang, R.G.1, Hou, E.H.1, Cheng, W.Q., Yan, X.T., Zhang, T.T., Li, S.H.,Yao, H.*, Liu, J. F.*,Guo, Y.*Membrane-targeting neolignan-antimicrobial peptide mimic conjugates to combat methicillin-resistantStaphylococcus aureus(MRSA) infections.Journal of Medicinal Chemistry,2022,65(24), 16879-16892.
6.Liu, Z.Y.1, Han, M.Y.1, Yan, X.T., Cheng, W.Q., Tang, Z.S., Cui, L.P.,Yang, R.G.*,Guo, Y.* Design,synthesis, andbiologicalevaluation ofnovelosthole-basedisoxazolinederivatives asinsecticidecandidates.Journal of Agricultural and Food Chemistry.2022, 70, 7921−7928.
7.Guo Y.*, Hou E. H., Ma N. N., Liu Z. Y., Fan J. P.,Yang R. G.*Discovery, biological evaluation and docking studies of novel N -acyl-2-aminothiazoles fused (+)-nootkatone fromCitrus paradisiMacf. as potentialα-glucosidase inhibitors.Bioorganic Chemistry,2020, 104, 104294.
招生方向：药学、天然药物化学
热烈欢迎对中药活性成分提取分离、天然产物结构优化、小分子药物合成、有机化学、抗感染药物材料及抗感染药理感兴趣的博士后、博士、硕士研究生以及本科生加入本课题组！
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