Private Information:
Country: China Gender: Male
Date of birth: 1975/12/06
Units of work: Department of Pharmacy, University of South China, Hengyang, Hunan Province
Zip code: 421001
Address: 28# Changsheng West Road, Hengyang city, Hunan province, Republic of China
Mobile Phone: +86-18390959848
Home Tel: +86-0734-8281782
Fax: +86-0734-8282914
Email:caoxuancx@gmail.com
09/2019-12/2020 Visiting Scholar inUniversity of California Riverside,College of chemistry and chemical engineering, USA.
10/2015-6/2018PhD of Analytical Chemistry, Doctoralstudent, Department of Chemistry,Tsinghua University, Beijing, China
06/2012-10/2015 PhD of Analytical Chemistry,Doctoralstudent, College of chemistry and chemical engineering, State Key Laboratory of Chemo/Biosensing and Chemo-metrics,Hunan University,Changsha, China
09/2000-06/2003 Master of Analytical Chemistry, College of chemistry and chemical engineering, State Key Laboratory of Chemo/Biosensing and Chemo-metrics,Hunan University, Changsha
6/1995 Bachelor ofChemistry,College ofChemistry,Hunan university of Humanities, Science andTechnology.
9/2003-Present Department ofPharmacy,University of South China, Hengyang, Hunan Province, China
(1) Xiaoyu Peng, Yang Li, Junfeng Qu, Lizhi Jiang, Kaiyue Wu, Dan Liu, Yuping Chen, Junmei Peng, Yu Guo,Xuan Cao*.High affinity and low PARP-trapping benzimidazole derivatives as a potential warhead for PARP1 degraders. European Journal of Medicinal Chemistry.2024, 271(5):116405.DOI:10.1016/j.ejmech.2024.116405.
(2)Yang Li, Junfeng Qu, Lizhi Jiang, Xiaoyu Peng, Kaiyue Wu, Miaojia Chen, Yuanyuan Peng,Xuan Cao*.Application and challenges of nitrogen heterocycles in PROTAC linker. European Journal of Medicinal Chemistry.2024, 273(5):116520.DOI:10.1016/j.ejmech.2024.116520.
(3)Yang Li, Lizhi Jiang, Junfeng Qu, Xiaoyu Peng, Kaiyue Wu, Miaojia Chen, Yuanyuan Peng,Xuan Cao*.Research Progress and Prospect of Nitrogen-containing Heterocycle in Anti-gastric Cancer Drugs: A Review. Current Medicinal Chemistry. 2024, 24(4). DOI:10.2174/0109298673296147240405113328
(4)Kaiyue Wu, Xiaoyu Peng, Yang Li, Miaojia Chen, Yunfan Liu, Dan Liu, Lizhi Jiang, Yan He, Junmei Peng*,Xuan Cao*.Design, synthesis, and evaluation of 1H-benzo[d]imidazole-4-carboxamide PARP-1 inhibitors using different saturated nitrogen-contained heterocycle as linker group. Chemical Biology & Drug Design.2023, 101(6): 1335-1347.DOI:10.1111/cbdd.14216
(5) Kaiyue Wu,Miaojia Chen,Xiaoyu Peng,Yang Li,Guotao Tang,Junmei Peng,Xuan Cao*.Recent progress of research onthe benzimidazole PARP-1 inhibitors, Mini-Reviews in Medicinal Chemistry.2022, 22(19): 2438-2462. DOI: 10.2174/1389557522666220321150700.
(6)Kaiyue Wu,Xiaoyu Peng,Miaojia Chen,Yang Li,Guotao Tang,Junmei Peng,Yuanyuan Peng,Xuan Cao*.Recent progress of research on anti-tumoragents usingbenzimidazole as the structure unit,Chemical Biology & Drug Design.2022, 99(5): 736-757.DOI: 10.1111/cbdd.14022.
(7)Miaojia Chen,Honglin Huang,Kaiyue Wu, GuotaoTang,Junmei Peng,Xuan Cao*.Synthesis and evaluation of 2-(4-[4-acetylpiperazine-1-carbonyl] phenyl)-1H-benzo[d]imidazole-4-carboxamidederivatives as potential PARP-1 inhibitors and preliminary study on structure-activityrelationship,Drug Development Research, 2021, 83(1): 55-63.DOI:10.1002/ddr.21843
(8) JinmeiQiu,Changfeng Qin,Shengen Wu,Tongying Ji, Guotao Tang,Xiaoyong Lei,Xuan Cao*, Zhizhong Xie*.A novel salvianolicacid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo. Drug Development Research, 2020, 82(6): 108-114.DOI:10.1002 /ddr.21734
(9)Jingjing Feng#,Xuan Cao#(co-author), Qi Pan, Yan He.* Direct observation of Single Plasmonic Metal Nanoparticle Reaction in Microcolumn with Chromatic-Aberration-Free Laser Light-Sheet Scattering Imaging.Electrophoresis, 2019, 40(13):1747-1753 DOI: 10.1002/elps.201900071
(10)Xuan Cao#, Gang Lei#, JingJing Feng, Qi Pan,YanHe.* A Novel Color Modulation Analysis Strategy through Tunable Multiband Laserfor Nanoparticle Identification and Evaluation,Analytical Chemistry, 2018, 90(4):2501-2507. DOI:10.1021/acs.analchem. 7b03636.
(11)Xuan Cao, Jingjing Feng, Qi Pan, Bin Xiong, Yan He,* and EdwardS. Yeung. Direct Imaging of Single Plasmonic Metal Nanoparticles in Capillary with Laser Light-Sheet Scattering Imaging. Analytical Chemistry, 2017. 89(2):2692-2697. DOI:10.1021 /acs.analchem.6b03844.
(12)Xiaodong Cheng,Xuan Cao, Bin Xiong,YanHe,* and Edward S.Yeung.Background-free three-dimensional selective imaging of anisotropicplasmonicnanoparticles.NanoResearch,2017.10(4):1423-1433.DOI: 10.1007/s12274-017-1524-4
(13)Lan Peng,Xuan Cao, Bin Xiong,*YanHe* and Edward S.Yeung.A novel scattering switch-on detection technique for target-induced plasmon-coupling based sensing by single-particleopticalanisotropy imaging. Chemical Communications, 2016, 52(2):7616-7619. DOI: 10.1039/ c6cc02536f
Research Interest
PharmaceuticalChemistry; medicinal Chemistry; Computational Chemistry
1)Design and total synthesis of small molecules such as PARP1 inhibitor.
2)Design and total synthesis ofNatural anti-tumoragents.(In progressing)
3)Data analysis or QSAR study of medicinal chemistry.
4)Theoretical calculations for the prediction of IC50of the compounds.
5)Theoretical calculations for the weak forcebased (non-covalent bond) molecular interactions.